Cefixime is a 3rd generation broad spectrum oral Cephalosporin. It acts by binding to PBP (Penicillin Binding Protein) receptor namely 1,1a, 1b, 3 and inhibits cell wall synthesis of bacteria. It is bactericidal in nature.
Ofloxacin is a 2nd generation Fluoroquinolone. It acts by inhibiting DNA gyrase II and Topoisomerase IV, thus inhibits DNA synthesis. It is bactericidal in nature. Ofloxacin is a broad spectrum antibiotic covering Gram positive, Gram negative and A typical bacteria.