Fexofenadine is a selective and non-sedating third generation antihistamine. Fexofenadine is histamine H1 receptor antagonist having an additional impact on the inflammatory mediators.
It does not cross the blood brain barrier and hence no sedation and is devoid of anticholinergic side effects.
Montelukast is a selective and orally active leukotriene receptor antagonist which inhibits the cysteinyl leukotriene 1 receptor, effective and well-tolerated preventive treatment for asthma and allergic rhinitis in adults and children. Montelukast effectively controls airway inflammation (upper & lower) induced by leukotriene.