Methotrexate is a goal standard in the treatment of rheumatoid arthritis. It belongs to the class of drugs known as antimetabollites which is often the first-line treatment in RA. It is also used in the treatment of psoriasis and juvenile rheumatoid arthritis. It inhibits the proliferation of RA related inflammatory cells through folate antagonism pathway and also exerts anti-inflammatory effects through adenosine signalling pathway. Methotrexate can be used as monotherapy and in combination with other conventional or synthetic DMARDs.
Indicated in the treatment of adults with rheumatoid arthritis, In active polyarticular-course juvenile rheumatoid arthritis, In treatment of adults with severe psoriasis