Our Solutions   RIFAPOL-H Tablets

RIFAPOL-H Tablets

RIFAPOL-H Tablets

*To be consumed as directed by physician.

Therapies:

Rheumatology

Composition:

Each RIFAPOL-H tablet contains:

  • Rifapentine 300 mg
  • Isoniazid 300 mg

About RIFAPOL-H Tablets

RIFAPOL-H is a prescription anti-tuberculosis medicine containing Rifapentine and Isoniazid, used for tuberculosis preventive treatment in eligible individuals.

It combines two antibiotics that act against Mycobacterium tuberculosis, the bacteria responsible for tuberculosis (TB).

Rifapentine inhibits bacterial RNA synthesis, while Isoniazid interferes with the production of mycolic acids, which are essential components of the bacterial cell wall.

Together, these medicines help prevent latent tuberculosis infection (LTBI) from progressing to active TB disease.

RIFAPOL-H may be prescribed as part of a short-course TB preventive treatment regimen under medical supervision.

RIFAPOL-H Tablets

*To be consumed as directed by physician.


Usage Instructions

  • Take RIFAPOL-H only as prescribed by your doctor.
  • Follow the recommended dosage and treatment schedule.
  • The Rifapentine-Isoniazid combination may be prescribed once weekly for 12 weeks as part of the 3HP regimen.
  • The number of tablets per dose depends on the prescribed regimen and patient characteristics.
  • Take the tablets with water, following your doctor's instructions regarding food.
  • Do not skip doses or discontinue treatment without medical advice.
  • Attend regular follow-ups to monitor treatment response and safety.

Note: RIFAPOL-H should not be taken daily unless specifically directed under an approved treatment regimen. Active TB disease must be excluded before initiating preventive treatment.


Benefits and Use

Latent Tuberculosis Infection (LTBI)

  • Helps prevent latent TB infection from progressing to active tuberculosis.
  • Targets tuberculosis bacteria through two complementary mechanisms.
  • Supports TB preventive treatment in appropriately selected individuals.

Tuberculosis Preventive Treatment (TPT)

  • Can be used as part of the three-month, once-weekly Rifapentine-Isoniazid regimen (3HP).
  • Provides a shorter treatment option compared with certain longer preventive regimens.
  • Supports treatment adherence when administered according to prescribed guidelines.

TB Prevention in High-Risk Individuals

  • May be prescribed to eligible individuals exposed to tuberculosis.
  • Supports preventive care in selected high-risk populations following medical evaluation.

Important: RIFAPOL-H is intended for preventive treatment in eligible patients. It should not be used alone to treat active tuberculosis.


Safety Information

Important Warnings

  • Liver Problems: Rifapentine and Isoniazid may cause liver injury. Patients with liver disease require careful assessment.
  • Allergic Reactions: Rash, fever and flu-like symptoms may occur.
  • Drug Interactions: Rifapentine may interact with several medicines, including certain HIV treatments, anticoagulants and hormonal contraceptives.
  • Peripheral Neuropathy: Isoniazid may cause tingling or numbness in the hands and feet.
  • Active Tuberculosis: Active TB must be excluded before starting preventive treatment to avoid inadequate therapy and potential drug resistance.

Common Side Effects

  • Nausea or vomiting.
  • Abdominal discomfort.
  • Headache.
  • Dizziness.
  • Fatigue.
  • Rash or itching.
  • Orange-red discolouration of urine, sweat or tears.

Precautions

Inform your doctor if you have:

  • Liver disease or hepatitis.
  • A history of tuberculosis treatment.
  • HIV infection or ongoing antiretroviral therapy.
  • Peripheral neuropathy.
  • Allergies to anti-tuberculosis medicines.
  • Pregnancy or plans to become pregnant.
  • Other ongoing medications.

Pregnancy and Breastfeeding

The 3HP regimen is generally not recommended during pregnancy because safety information remains limited. Pregnant or breastfeeding patients should consult their physician for an appropriate treatment plan.

Medical Monitoring

Regular medical assessment and liver function monitoring may be required.

Seek immediate medical attention for jaundice, severe abdominal pain, persistent vomiting, unusual bleeding, breathing difficulties or severe allergic reactions.


Ingredients

Active Ingredients:

  • Rifapentine 300 mg.
  • Isoniazid 300 mg.

Inactive Ingredients:

Pharmaceutical excipients that support tablet formulation, stability and administration.

The complete list of inactive ingredients should be confirmed from the approved RIFAPOL-H package insert.


How to Use

  • Step 1: Consult your doctor and confirm eligibility for TB preventive treatment.
  • Step 2: Take the prescribed number of tablets according to the recommended schedule.
  • Step 3: Follow the administration instructions provided by your healthcare professional.
  • Step 4: Complete the prescribed treatment course without skipping scheduled doses.
  • Step 5: Attend regular medical follow-ups and recommended laboratory tests.
  • Step 6: Report unusual symptoms, suspected side effects or missed doses to your doctor.
  • Step 7: Do not change or discontinue treatment without medical advice.

Storage Information

  • Store according to the temperature instructions on the product label.
  • Keep tablets in their original packaging.
  • Protect from excessive heat, moisture and direct sunlight.
  • Keep out of reach of children and pets.
  • Do not use after the expiry date.
  • Consult a pharmacist for safe disposal of unused medicines.

The exact storage temperature should be confirmed from the approved RIFAPOL-H product packaging.

Disclaimer

RIFAPOL-H is a prescription-only medicine. This information is intended for educational purposes and does not replace professional medical advice.

Use only under the supervision of a qualified healthcare professional. Refer to the approved Indian prescribing information for complete details regarding indications, dosage, contraindications, warnings and precautions.