Description:
Methylprednisolone suppresses the immune system by reducing activity and volume of the lymphatic system, thus producing lymphocytopenia (primarily of T lymphocytes), decreasing immunoglobulin and complement levels, decreasing passage of immune complexes through basement membranes, and possibly by depressing reactivity of tissue to antigen-antibody interactions. As a corticosteroid, methylprednisolone also suppresses the synthesis of cyclooxygenase (COX)-2, an enzyme that produces prostaglandins in damaged tissue and contributes to the inflammation cascade.
Methylprednisolone impair various T-cell functions; moderate and high doses induce T-cell apoptosis while preserving B-cell functions, including antibody production. Methylprednisolone can be used as a intramuscular or intra-articular injection.
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