Description:
Hydroxychloroquine (HCQ) is a antimalarial drug which is also used as a disease-modifying agent for the treatment of various rheumatic diseases. HCQ can block Toll-like receptors 7 and 9 in dendritic cells and inhibit lysosomes to increase intracellular pH, which facilitates appropriate antigen presentation.
HCQ also inhibits the overactivation of B cells and reduce antibody production. In addition, HCQ inhibits platelet aggregation and reduces arachidonic acid production thus reducing the complications of thrombosis in RA and SLE. It can be used safely in pregnant women. HCQ can be preferred as monotherapy or in combination with other csDMARDs in case of inadequate response or intolerance to methotrexate.
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